Investigating how proteins help maintain the structure of the cell nucleus in aging.
Official title: Understanding the role of tether proteins to maintain chromatin-nuclear lamina contacts in premature aging.
Funded at University of Pennsylvania · NIH-10839873 · Data updated 2026-11-12
This study is looking at how certain proteins help keep the cell's nucleus organized and how changes in these proteins might relate to aging conditions like progeria, with a focus on a protein called PRR14 to better understand how it affects the structure of our cells.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 15, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $203,125 |
| NIH project number | 5R21AG081795-02 |
| Project ID | NIH-10839873 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Hutchinson-Gilford progeria syndrome or other related premature aging disorders.
✕Less likely to help
Patients with unrelated genetic disorders or those not exhibiting symptoms of premature aging may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific proteins that tether chromatin to the nuclear lamina, which is crucial for maintaining the structure of the cell nucleus. The study aims to explore how mutations in these proteins, particularly in relation to premature aging conditions like Hutchinson-Gilford progeria syndrome, affect the organization of chromatin and the integrity of the nuclear lamina. By examining the protein PRR14, the researchers will investigate its impact on chromatin positioning and nuclear structure, which could provide insights into the mechanisms of aging at the cellular level.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing conditions associated with premature aging.
How similar studies have gone: Previous research has shown promising results in understanding the role of nuclear lamina mutations in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Poleshko, Andrey — University of Pennsylvania
- Study coordinator: Poleshko, Andrey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.