Investigating how proteins change shape at room temperature
Official title: Room Temperature Protein Conformational Dynamics at Microsecond Timescales
Funded at Cornell University · NIH-10932875 · Data updated 2026-11-12
This study is looking at how proteins move and behave, which is important for figuring out how diseases start and how we can treat them better, using special techniques to see these movements clearly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | September 25, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $384,989 |
| NIH project number | 5R35GM151218-02 |
| Project ID | NIH-10932875 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to protein misfolding or dysfunction, such as neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to protein dynamics or those who do not have a protein-related disorder may not benefit from this research.
What this research studies
This research focuses on understanding the dynamics of protein molecules, which is crucial for revealing how diseases develop and how they can be treated. By using advanced techniques like multi-frequency Electron Spin Resonance (ESR) spectroscopy, the study aims to observe protein movements at room temperature over microsecond timescales. The researchers will develop new computational methods to enhance the clarity of these observations, allowing for better insights into protein behavior and interactions. This could lead to improved strategies for early diagnosis and drug development.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in early disease diagnosis and more effective treatments by providing deeper insights into protein dynamics.
How similar studies have gone: Other research has shown promise in using advanced spectroscopy techniques to study protein dynamics, indicating that this approach could yield valuable insights.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Srivastava, Madhur — Cornell University
- Study coordinator: Srivastava, Madhur
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.