Investigating how proteins behave differently in various cell types in human diseases
Official title: Integrative Approaches to Study Cell-Type-Specific Protein Dysregulation in Human Diseases
Funded at University of Alabama at Birmingham · NIH-10938179 · Data updated 2026-11-12
This study is looking at how certain proteins behave differently in various cells related to diseases like Alzheimer's and cancer, with the goal of finding new ways to treat these conditions and help patients get more personalized care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $358,640 |
| NIH project number | 1R35GM154953-01 |
| Project ID | NIH-10938179 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or other complex conditions characterized by protein dysregulation.
✕Less likely to help
Patients with non-complex diseases or those not exhibiting significant protein dysregulation may not benefit from this research.
What this research studies
This research focuses on understanding the specific protein dysregulation in different cell types associated with complex diseases like Alzheimer's and cancer. By utilizing advanced techniques such as single-cell RNA sequencing and mass spectrometry, the study aims to profile protein-level changes that occur in these diseases. This approach will help identify potential biomarkers and therapeutic targets, ultimately leading to better treatment strategies. Patients may benefit from insights gained about their specific disease mechanisms and tailored therapies based on their unique cellular profiles.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with complex diseases.
How similar studies have gone: Previous research has shown promise in using proteogenomics to understand disease mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Huang, Chen — University of Alabama at Birmingham
- Study coordinator: Huang, Chen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.