Investigating how proteins behave at room temperature over microsecond timescales
Official title: Room Temperature Protein Conformational Dynamics at Microsecond Timescales
Funded at Cornell University · NIH-11102595 · Data updated 2026-11-12
This study is looking at how proteins move and interact in real-time to help us understand diseases better, which could lead to new ways to diagnose and treat them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | September 25, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $118,359 |
| NIH project number | 3R35GM151218-02S1 |
| Project ID | NIH-11102595 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to protein misfolding or dysfunction, such as neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to protein dynamics or those who do not have a protein-related disease may not benefit from this research.
What this research studies
This research focuses on understanding the dynamics of proteins, which are crucial for determining how diseases develop and how they can be treated. By using advanced techniques like multi-frequency Electron Spin Resonance (ESR) spectroscopy, the study aims to observe protein movements and interactions in real-time at physiological temperatures. The researchers will develop new computational methods to enhance the clarity of these observations, allowing for better insights into protein behavior that could lead to improved diagnostics and therapies.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and more effective treatments for various diseases by providing deeper insights into protein dynamics.
How similar studies have gone: Previous research using similar ESR techniques has shown promise in understanding protein dynamics, indicating that this approach could yield valuable insights.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Srivastava, Madhur — Cornell University
- Study coordinator: Srivastava, Madhur
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.