Investigating how proteins and RNA interact to form cellular structures.
Multi-scale computational investigation of functions and mechanisms of protein-RNA phase separation.
This study is looking into how proteins and RNA work together to form special structures in our cells that don’t have membranes, and it hopes to uncover how these structures affect gene activity and cell functions, which could help people with degenerative neurological disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project ID | NIH-10912736 on NIH RePORTER |
What this research studies
This research explores the phenomenon of liquid-liquid phase separation, where proteins and RNA come together to form membraneless organelles within cells. By utilizing advanced computational tools, the study aims to understand the mechanisms that link these phase separations to gene regulation and cellular functions. The approach involves analyzing the complex interactions at both molecular and cellular levels, addressing challenges such as molecular heterogeneity and non-equilibrium biochemical processes. Patients may benefit from insights gained about the role of these processes in degenerative neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with degenerative neurological disorders linked to protein-RNA interactions.
Not a fit: Patients with conditions unrelated to protein-RNA phase separation or those not experiencing degenerative neurological disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for understanding and potentially treating degenerative neurological disorders.
How similar studies have performed: Other research has shown promise in understanding protein-RNA interactions, but this specific multi-scale computational approach is relatively novel.
Where this research is happening
Ames, United States
- Iowa State University — Ames, United States (Active)
Researchers
- Principal investigator: Potoyan, Davit — Iowa State University
- Study coordinator: Potoyan, Davit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.