Investigating how proteins affect cellular processes related to diabetes
Official title: Processes mediated by polypeptides
Funded at University of Wisconsin-Madison · NIH-11014356 · Data updated 2026-11-12
This study is looking at how certain proteins work in the body and how they might be linked to adult-onset diabetes, with the hope of finding new ways to help manage the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $578,813 |
| NIH project number | 5R35GM151985-02 |
| Project ID | NIH-11014356 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with adult-onset diabetes or those experiencing related metabolic issues.
✕Less likely to help
Patients with conditions unrelated to protein signaling or those not affected by diabetes may not benefit from this research.
What this research studies
This research explores the role of proteins in cellular functions that are often disrupted in diseases like adult-onset diabetes. By using chemically synthesized polypeptides, the team aims to understand how these proteins interact with specific receptors in the body, particularly those involved in hormone signaling. The study focuses on G protein-coupled receptors (GPCRs) that are influenced by long polypeptide hormones, which are important for regulating blood sugar levels and other physiological processes. The findings could lead to new therapeutic strategies for managing diabetes and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetes and enhance our understanding of related metabolic disorders.
How similar studies have gone: Previous research has shown promise in understanding GPCRs and their role in diabetes treatment, indicating that this approach has potential for success.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Gellman, Samuel H. — University of Wisconsin-Madison
- Study coordinator: Gellman, Samuel H.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.