Investigating how protein structures affect their functions and roles in diseases.
Official title: Function and Pathway outcomes of Dynamic Protein Structures
Funded at Miami University Oxford · NIH-11004077 · Data updated 2026-11-12
This study is looking at how proteins change shape and how those changes can affect their roles in our bodies, especially in relation to antibiotic resistance and diseases like cancer and neurodegenerative disorders, to help us understand why proteins sometimes misfold and how that impacts our health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Miami University Oxford NIH-funded |
| Lab location | 1 site (Oxford, United States) |
| Project start | September 1, 2018 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $308,778 |
| NIH project number | 5R35GM128595-07 |
| Project ID | NIH-11004077 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with neurodegenerative disorders, ataxias, or cancers, as well as those affected by antibiotic-resistant infections.
✕Less likely to help
Patients with conditions unrelated to protein misfolding or antibiotic resistance may not benefit from this research.
What this research studies
This research focuses on understanding the dynamic structures of proteins and how these structures influence their functions in cellular processes, particularly in relation to antibiotic resistance and various diseases like neurodegenerative disorders and cancers. By examining the interactions between proteins and their environments, the study aims to uncover the mechanisms that lead to protein misfolding and the subsequent cellular responses. The research employs advanced techniques to analyze protein dynamics and their implications for health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases associated with protein misfolding and antibiotic resistance.
How similar studies have gone: Previous research has shown promising results in understanding protein dynamics and their roles in diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
Miami University Oxford
Oxford, United States Active
Researchers
- Principal investigator: Page, Richard C — Miami University Oxford
- Study coordinator: Page, Richard C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.