Investigating how protein stress affects brain function in Alzheimer's disease
Chaperome networks in Alzheimer's disease
This study is looking at how stress from certain proteins in the brain affects the connections between nerve cells, which can lead to memory problems in people with Alzheimer's disease, and the researchers hope to find ways to fix these issues and improve brain function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11012280 on NIH RePORTER |
What this research studies
This research focuses on understanding how stress caused by amyloid-beta and tau proteins disrupts the connections between neurons, leading to cognitive issues in Alzheimer's disease. The team will explore how these proteins cause changes in neuronal circuits and overall brain function. By using advanced cellular models derived from induced pluripotent stem cells (iPSCs), the researchers aim to identify the mechanisms behind synaptic dysfunction and memory loss. The ultimate goal is to find ways to restore normal protein function and connectivity in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing cognitive decline associated with age.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve cognitive function in Alzheimer's patients.
How similar studies have performed: Previous studies have shown promising results in understanding the role of protein stress in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Chiosis, Gabriela — Sloan-Kettering Inst Can Research
- Study coordinator: Chiosis, Gabriela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.