Investigating how protein signaling affects stomach cancer development
Role of Protein Kinase A (PKA)-mediated mesenchymal-epithelial crosstalk in gastric preneoplasia
['FUNDING_OTHER'] · TUSKEGEE UNIVERSITY · NIH-11081738
This study is looking at how a specific protein in your stomach helps cells talk to each other during inflammation from H. pylori infection, with the goal of finding new ways to prevent or treat early changes that could lead to stomach cancer, especially for those who have had issues with H. pylori.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUSKEGEE UNIVERSITY (nih funded) |
| Locations | 1 site (TUSKEGEE INSTITUTE, UNITED STATES) |
| Trial ID | NIH-11081738 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of protein kinase A (PKA) in the communication between stomach tissue and surrounding cells, particularly in the context of inflammation caused by H. pylori infection. The study aims to uncover how this signaling pathway contributes to the development of preneoplastic lesions, which are early changes that can lead to stomach cancer. By exploring these mechanisms, the research seeks to identify potential new therapies that could prevent or treat these lesions effectively. Patients with a history of H. pylori infection or related gastric conditions may find this research particularly relevant.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of H. pylori infection or those diagnosed with atrophic gastritis or other gastric preneoplastic conditions.
Not a fit: Patients who have not been infected with H. pylori or do not have any gastric conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the progression of early gastric lesions into cancer.
How similar studies have performed: Previous research has shown that targeting inflammatory pathways can be effective in reducing cancer risk, suggesting that this approach may hold promise.
Where this research is happening
TUSKEGEE INSTITUTE, UNITED STATES
- TUSKEGEE UNIVERSITY — TUSKEGEE INSTITUTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PURI, PAWAN — TUSKEGEE UNIVERSITY
- Study coordinator: PURI, PAWAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.