Investigating how protein signaling affects stomach cancer development
Official title: Role of Protein Kinase A (PKA)-mediated mesenchymal-epithelial crosstalk in gastric preneoplasia
Funded at Tuskegee University · NIH-11081738 · Data updated 2026-11-12
This study is looking at how a specific protein in your stomach helps cells talk to each other during inflammation from H. pylori infection, with the goal of finding new ways to prevent or treat early changes that could lead to stomach cancer, especially for those who have had issues with H. pylori.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tuskegee University NIH-funded |
| Lab location | 1 site (Tuskegee Institute, United States) |
| Project start | July 17, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $147,000 |
| NIH project number | 5R16GM149389-03 |
| Project ID | NIH-11081738 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of H. pylori infection or those diagnosed with atrophic gastritis or other gastric preneoplastic conditions.
✕Less likely to help
Patients who have not been infected with H. pylori or do not have any gastric conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of protein kinase A (PKA) in the communication between stomach tissue and surrounding cells, particularly in the context of inflammation caused by H. pylori infection. The study aims to uncover how this signaling pathway contributes to the development of preneoplastic lesions, which are early changes that can lead to stomach cancer. By exploring these mechanisms, the research seeks to identify potential new therapies that could prevent or treat these lesions effectively. Patients with a history of H. pylori infection or related gastric conditions may find this research particularly relevant.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the progression of early gastric lesions into cancer.
How similar studies have gone: Previous research has shown that targeting inflammatory pathways can be effective in reducing cancer risk, suggesting that this approach may hold promise.
Where this research is happening
-
Tuskegee University
Tuskegee Institute, United States Active
Researchers
- Principal investigator: Puri, Pawan — Tuskegee University
- Study coordinator: Puri, Pawan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.