Investigating how Protein S affects blood clot risk in obese women using contraceptives
A Mechanistic Study to elucidate the role of Protein S in elevating the risk of Thrombosis in Obese, Pre-menopausal women
This study is looking at how being obese and using birth control pills affects a protein that helps prevent blood clots in women who haven't gone through menopause yet, with the goal of finding ways to lower the risk of serious blood clots for those women.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10799549 on NIH RePORTER |
What this research studies
This research explores the role of Protein S, a protein that helps prevent blood clots, in obese, pre-menopausal women who use oral contraceptives. It aims to understand how obesity and contraceptive use individually and together influence levels of Protein S and increase the risk of thrombosis, which can lead to serious conditions like stroke and deep vein thrombosis. The study will involve biochemical and molecular analyses to uncover the mechanisms behind these risks, potentially leading to better prevention strategies for affected women.
Who could benefit from this research
Good fit: Ideal candidates for this research are obese, pre-menopausal women who are using oral contraceptives.
Not a fit: Patients who are not obese or who do not use oral contraceptives may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of thrombotic risks in obese women using contraceptives.
How similar studies have performed: Previous research has indicated that hormonal factors significantly influence thrombotic risks, suggesting that this study's approach is built on established findings, though the specific focus on obesity and oral contraceptives is less explored.
Where this research is happening
New Orleans, United States
- Lsu Health Sciences Center — New Orleans, United States (Active)
Researchers
- Principal investigator: Majumder, Rinku — Lsu Health Sciences Center
- Study coordinator: Majumder, Rinku
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.