Investigating how protein-nanoparticle interactions affect communication in ovarian tumors
Official title: Protein-nanoparticle interaction to study multicellular crosstalk within ovarian tumor microenviroment
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-11029951 · Data updated 2026-11-12
This study is looking at how tiny gold particles can help us understand how cells in ovarian tumors talk to each other, with the hope of finding better ways to treat ovarian cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | January 16, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $326,103 |
| NIH project number | 1R01CA297076-01 |
| Project ID | NIH-11029951 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with ovarian cancer who are seeking new treatment options.
✕Less likely to help
Patients with non-ovarian cancers or those who are not currently undergoing treatment for ovarian cancer may not benefit from this research.
What this research studies
This research explores the interactions between proteins and nanoparticles to understand how different cells communicate within the ovarian tumor microenvironment. By using gold nanoparticles, which have shown potential anti-cancer properties, the study aims to uncover the mechanisms behind tumor growth and resistance to treatment. The approach involves using patient-derived models to simulate the tumor environment and observe how these nanoparticles can disrupt harmful cellular interactions. This could lead to new insights into ovarian cancer treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve outcomes for patients with ovarian cancer.
How similar studies have gone: Previous research has shown promise in using nanoparticles for cancer treatment, indicating that this approach could be a valuable addition to existing therapies.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Mukherjee, Priyabrata — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Mukherjee, Priyabrata
Related research
Other NIH-funded projects on the same topics.
-
Primary care research network in Oklahoma to boost rural patient trials
A nationwide NIH-supported effort to strengthen Oklahoma’s primary care research network so doctors can run big clinical trials and real‑world studies in rural communities.
-
N-myristoylation and DNA damage response in Alzheimer’s disease
A study to understand how a protein modification called myristoylation affects the DNA damage response in people who have Alzheimer’s-related conditions.
-
Genetically engineered mouse model to study and treat high-risk pediatric rhabdomyosarcoma
A research project aims to create mouse models that mimic high-risk pediatric rhabdomyosarcoma and test therapies that target the NOTCH1 pathway to slow or stop tumor growth.
-
Understanding how bone cancer cells rely on certain pathways to grow in childhood osteosarcoma
This grant studies how specific cancer-related pathways in bone-forming cells drive osteosarcoma in children, with the aim of finding better treatments.
-
Vascular signals from brain blood vessels influence immune-suppressing cells in glioblastoma
This grant explores how blood vessel cells in glioblastoma shape immune cells to help the tumor grow, with the aim of making immunotherapies work better for patients.
-
TFEB as a key switch to keep muscles healthy as we age
A study in aging adults and aging muscle tissues looks at whether boosting TFEB can improve how muscles maintain themselves and recover after disuse.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.