Investigating how protein modifications affect heart function in patients with heart failure.
Protein acetylation-dependent fatty acid metabolic dysfunction in HFpEF
['FUNDING_CAREER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11016957
This study is looking at heart failure with preserved ejection fraction (HFpEF) to understand how certain proteins and energy problems in heart cells affect heart health, with the hope of finding new treatments that could help people with this condition.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11016957 on ClinicalTrials.gov |
What this research studies
This research focuses on heart failure with preserved ejection fraction (HFpEF), a condition affecting about half of all heart failure patients. It aims to understand the underlying mechanisms of HFpEF by studying mitochondrial dysfunction and protein acetylation in a novel mouse model that mimics human HFpEF. The researchers will explore how specific proteins influence heart function and whether targeting these proteins can improve cardiac health. Patients may benefit from insights that could lead to new treatments for HFpEF.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure with preserved ejection fraction, particularly those with coexisting metabolic conditions.
Not a fit: Patients with heart failure with reduced ejection fraction or those without metabolic disturbances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating heart failure with preserved ejection fraction.
How similar studies have performed: Previous research has shown promising results in targeting metabolic dysfunctions in heart failure, suggesting potential for success in this novel approach.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TONG, DAN — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: TONG, DAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.