Investigating how protein maintenance changes during aging and Alzheimer's disease
Studying Neuronal Proteostasis During Aging and AD with Novel Protein Tagging Tools
This study is looking at how aging and Alzheimer's disease affect the way proteins are made and maintained in the brain, using a special technique to track these proteins in real time, which could help us understand more about brain health and the changes that happen with Alzheimer's.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10947048 on NIH RePORTER |
What this research studies
This research focuses on understanding how the maintenance of proteins in the brain is affected by aging and Alzheimer's disease (AD). It uses a novel technique called bioorthogonal non-canonical amino acid tagging (BONCAT) to track newly synthesized proteins in living models. By analyzing these proteins over time, researchers aim to uncover the dynamics of protein turnover and its implications for neuron health. This could lead to insights into the mechanisms behind neurodegeneration in AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing early signs of Alzheimer's disease or those at risk due to age or genetic factors.
Not a fit: Patients with advanced Alzheimer's disease or those with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for maintaining brain health and potentially slowing the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding protein dynamics in neurodegenerative diseases, making this approach both relevant and potentially impactful.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Guldner, Ian Hunter — Stanford University
- Study coordinator: Guldner, Ian Hunter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.