Investigating how protein maintenance changes during aging and Alzheimer's disease
Official title: Studying Neuronal Proteostasis During Aging and AD with Novel Protein Tagging Tools
Funded at Stanford University · NIH-10947048 · Data updated 2026-11-12
This study is looking at how aging and Alzheimer's disease affect the way proteins are made and maintained in the brain, using a special technique to track these proteins in real time, which could help us understand more about brain health and the changes that happen with Alzheimer's.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 8, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $131,027 |
| NIH project number | 1K99AG088304-01 |
| Project ID | NIH-10947048 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing early signs of Alzheimer's disease or those at risk due to age or genetic factors.
✕Less likely to help
Patients with advanced Alzheimer's disease or those with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research focuses on understanding how the maintenance of proteins in the brain is affected by aging and Alzheimer's disease (AD). It uses a novel technique called bioorthogonal non-canonical amino acid tagging (BONCAT) to track newly synthesized proteins in living models. By analyzing these proteins over time, researchers aim to uncover the dynamics of protein turnover and its implications for neuron health. This could lead to insights into the mechanisms behind neurodegeneration in AD.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for maintaining brain health and potentially slowing the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding protein dynamics in neurodegenerative diseases, making this approach both relevant and potentially impactful.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Guldner, Ian Hunter — Stanford University
- Study coordinator: Guldner, Ian Hunter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.