Investigating how protein kinases control cell growth and immune responses
Mechanistic studies of protein kinases
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-11014850
This study is looking at how certain proteins in our cells work together to control growth and immune responses, which could help us find new treatments for diseases like cancer and developmental disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11014850 on ClinicalTrials.gov |
What this research studies
This research explores the role of protein kinases, which are enzymes that modify proteins through phosphorylation, influencing various cellular processes such as growth and immune responses. By focusing on the Hippo pathway, a key regulator of cell fate, the research aims to uncover the molecular mechanisms that control kinase activity. Utilizing a combination of biophysical, biochemical, structural bioinformatics, and cellular methods, the study seeks to fill knowledge gaps regarding kinase regulation and identify new ways to modulate this pathway. The insights gained could lead to the development of targeted therapies for diseases like cancer and developmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by cancers or developmental disorders linked to protein kinase activity.
Not a fit: Patients with conditions unrelated to protein kinase activity or those not affected by cancer or developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that effectively block harmful kinase activity, improving treatment options for various diseases.
How similar studies have performed: Previous research has shown promising results in targeting protein kinases for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAVRAN, JENNIFER MARIE — JOHNS HOPKINS UNIVERSITY
- Study coordinator: KAVRAN, JENNIFER MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer, Cancers