Investigating how protein kinases control cell growth and immune responses
Official title: Mechanistic studies of protein kinases
Funded at Johns Hopkins University · NIH-11014850 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells work together to control growth and immune responses, which could help us find new treatments for diseases like cancer and developmental disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 3, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $387,500 |
| NIH project number | 1R35GM156573-01 |
| Project ID | NIH-11014850 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by cancers or developmental disorders linked to protein kinase activity.
✕Less likely to help
Patients with conditions unrelated to protein kinase activity or those not affected by cancer or developmental disorders may not benefit from this research.
What this research studies
This research explores the role of protein kinases, which are enzymes that modify proteins through phosphorylation, influencing various cellular processes such as growth and immune responses. By focusing on the Hippo pathway, a key regulator of cell fate, the research aims to uncover the molecular mechanisms that control kinase activity. Utilizing a combination of biophysical, biochemical, structural bioinformatics, and cellular methods, the study seeks to fill knowledge gaps regarding kinase regulation and identify new ways to modulate this pathway. The insights gained could lead to the development of targeted therapies for diseases like cancer and developmental disorders.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that effectively block harmful kinase activity, improving treatment options for various diseases.
How similar studies have gone: Previous research has shown promising results in targeting protein kinases for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Kavran, Jennifer Marie — Johns Hopkins University
- Study coordinator: Kavran, Jennifer Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.