Investigating how protein changes relate to lysosomal failure in Alzheimer's disease
Connecting long-lived protein isomerization to lysosomal failure in Alzheimer's disease
This study is looking at how changes in certain proteins related to Alzheimer's disease might affect the way our cells recycle them, which could help us understand the disease better and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-10816445 on NIH RePORTER |
What this research studies
This research explores the connection between spontaneous modifications in long-lived proteins and the causes of Alzheimer's disease (AD). It focuses on two specific proteins, tau and amyloid beta, which are crucial in AD progression. By utilizing advanced detection technologies, the study aims to characterize these protein modifications, known as isomerization and epimerization, and understand how they affect protein recycling in lysosomes. The findings could reveal new insights into the mechanisms of AD and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing Alzheimer's disease.
How similar studies have performed: While the specific approach of investigating protein isomerization in AD is relatively novel, similar studies have shown promise in understanding protein behavior in neurodegenerative diseases.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Julian, Ryan Roy — University of California Riverside
- Study coordinator: Julian, Ryan Roy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.