Investigating how protein changes affect heart remodeling
Alternative Protein Isoforms in Ventricular Remodeling
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-11077207
This study is looking at how changes in RNA can affect heart growth and function, and it's using mice to find out which proteins are involved, so we can better understand heart disease and help patients in the future.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11077207 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how alternative splicing of RNA influences the development of cardiac hypertrophy and heart failure. By using advanced proteomics techniques, the study aims to identify specific protein isoforms that result from these splicing changes and how they impact heart function. The research will utilize mouse models to explore the mechanisms behind these changes and their implications for heart health. Patients may benefit from insights gained into the molecular processes that contribute to heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiac hypertrophy or heart failure.
Not a fit: Patients with non-cardiac related conditions or those without any heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating heart failure and improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using proteomics and RNA sequencing to understand cardiac diseases, indicating that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAM, MAGGIE — UNIVERSITY OF COLORADO DENVER
- Study coordinator: LAM, MAGGIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.