Investigating how protein changes affect brain aging
Official title: Understanding protein turnover alterations in physiological brain aging
Funded at Columbia Univ New York Morningside · NIH-10790402 · Data updated 2026-11-12
This study is looking at how changes in proteins in the brain as we age might affect our thinking and memory, with the hope of finding new ways to help people with age-related brain issues like Alzheimer's.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $412,751 |
| NIH project number | 1R21AG085062-01 |
| Project ID | NIH-10790402 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older, particularly those experiencing cognitive decline or at risk for Alzheimer's disease.
✕Less likely to help
Patients who are younger than 21 or do not have any cognitive impairments may not benefit from this research.
What this research studies
This research focuses on understanding how alterations in protein turnover contribute to the aging process in the brain. It aims to explore the mechanisms behind reduced proteome integrity, which is linked to cognitive decline and neurodegenerative diseases like Alzheimer's. By employing advanced techniques such as metabolic labeling and quantitative proteomics, the study seeks to uncover the molecular changes that occur with aging and their potential impact on brain health. Patients may benefit from insights that could lead to new therapeutic strategies for age-related cognitive impairments.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve brain health and cognitive function in aging individuals.
How similar studies have gone: Previous research has shown that understanding protein homeostasis can lead to significant advancements in treating neurodegenerative diseases, indicating a promising avenue for this study.
Where this research is happening
-
Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Jovanovic, Marko — Columbia Univ New York Morningside
- Study coordinator: Jovanovic, Marko
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.