Investigating how protein C interacts with thrombin to regulate blood coagulation
Structural enzymology of protein C
This study is looking at how a protein called thrombin interacts with another protein called protein C, which helps control blood clotting, to better understand how these proteins work together and possibly improve treatments for blood clotting issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11079588 on NIH RePORTER |
What this research studies
This research focuses on understanding the interaction between thrombin and the anticoagulant protein C, which plays a crucial role in regulating blood clotting. Using advanced techniques like cryo-electron microscopy, the study aims to uncover the structural details of protein C and its complexes, which are essential for maintaining a balanced coagulation response. By filling gaps in our knowledge about these interactions, the research seeks to enhance our understanding of blood coagulation mechanisms and potentially lead to improved anticoagulant therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with clotting disorders or those at risk of thrombotic events.
Not a fit: Patients with no history of blood coagulation issues or those not affected by thrombotic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for conditions related to abnormal blood clotting, such as thrombosis.
How similar studies have performed: Other research has successfully utilized structural approaches like cryo-EM to advance our understanding of blood coagulation factors, indicating a promising avenue for this study.
Where this research is happening
Saint Louis, United States
- Saint Louis University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Di Cera, Enrico — Saint Louis University
- Study coordinator: Di Cera, Enrico
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.