Investigating how protein assemblies control metabolism in cells
Off the beaten path(way): Spatiotemporal investigation of protein assemblies controlling mitochondrial metabolism
This study is looking at how certain proteins and fats work together to help our cells use energy, and it aims to understand how problems with these proteins might affect our health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11013611 on NIH RePORTER |
What this research studies
This research explores the complex networks of proteins and lipids that regulate cellular metabolism, focusing on a specific group of proteins known as the heme metabolon. By using advanced techniques like cryo-electron microscopy and time-resolved proteomics, the team aims to isolate and understand the structure and dynamics of these protein assemblies. This knowledge could reveal how defects in these processes affect metabolic functions, which is crucial for various biological systems, including human health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders or conditions related to heme metabolism.
Not a fit: Patients with unrelated metabolic conditions or those not affected by heme metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into metabolic disorders and improve treatments for conditions like diabetes.
How similar studies have performed: Other research has shown success in understanding protein assemblies and their roles in metabolism, indicating that this approach has potential for significant findings.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Brown, Breann — Vanderbilt University
- Study coordinator: Brown, Breann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.