Investigating how protein arginine methylation affects gene expression and cellular function
Protein arginine methylation in transcription and RNA metabolism
['FUNDING_OTHER'] · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · NIH-11011846
This study is looking at how a special change to proteins, called arginine methylation, affects how our genes work and could play a role in diseases like cancer and brain disorders, with the hope that what we learn can help develop new treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BECKMAN RESEARCH INSTITUTE/CITY OF HOPE (nih funded) |
| Locations | 1 site (DUARTE, UNITED STATES) |
| Trial ID | NIH-11011846 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of protein arginine methylation, a crucial modification that influences gene expression and cellular processes. By studying how this modification is added and recognized by specific proteins, the research aims to uncover its impact on various diseases, including cancer and neurodevelopmental disorders. The approach involves detailed molecular analysis to identify the pathways through which arginine methylation regulates gene activity and cellular signaling. Patients may benefit from insights gained into how these processes contribute to disease, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with cancers or neurodevelopmental disorders that may be influenced by gene expression regulation.
Not a fit: Patients with conditions unrelated to gene expression or protein modifications may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to abnormal protein arginine methylation, such as certain cancers and neurodevelopmental disorders.
How similar studies have performed: Previous research has shown promising results in understanding protein modifications and their roles in disease, suggesting that this approach could yield valuable insights.
Where this research is happening
DUARTE, UNITED STATES
- BECKMAN RESEARCH INSTITUTE/CITY OF HOPE — DUARTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, YANZHONG — BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- Study coordinator: YANG, YANZHONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers