Investigating how protein arginine methylation affects gene expression and cellular function
Official title: Protein arginine methylation in transcription and RNA metabolism
Funded at Beckman Research Institute/city of Hope · NIH-11011846 · Data updated 2026-11-12
This study is looking at how a special change to proteins, called arginine methylation, affects how our genes work and could play a role in diseases like cancer and brain disorders, with the hope that what we learn can help develop new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | January 23, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $445,000 |
| NIH project number | 1R35GM156316-01 |
| Project ID | NIH-11011846 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with cancers or neurodevelopmental disorders that may be influenced by gene expression regulation.
✕Less likely to help
Patients with conditions unrelated to gene expression or protein modifications may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of protein arginine methylation, a crucial modification that influences gene expression and cellular processes. By studying how this modification is added and recognized by specific proteins, the research aims to uncover its impact on various diseases, including cancer and neurodevelopmental disorders. The approach involves detailed molecular analysis to identify the pathways through which arginine methylation regulates gene activity and cellular signaling. Patients may benefit from insights gained into how these processes contribute to disease, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to abnormal protein arginine methylation, such as certain cancers and neurodevelopmental disorders.
How similar studies have gone: Previous research has shown promising results in understanding protein modifications and their roles in disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Yang, Yanzhong — Beckman Research Institute/city of Hope
- Study coordinator: Yang, Yanzhong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.