Investigating how propionate metabolism affects non-small cell lung cancer
Official title: The Role of Propionate Metabolism in Non-Small Cell Lung Cancer
Funded at Weill Medical Coll of Cornell Univ · NIH-11113801 · Data updated 2026-11-12
This study is looking at how a substance called methylmalonic acid affects the growth and treatment resistance of non-small cell lung cancer, and it invites patients to help by providing blood samples to better understand this connection and find new treatment options.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 12, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $196,020 |
| NIH project number | 5K08CA279653-02 |
| Project ID | NIH-11113801 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with non-small cell lung cancer, particularly those experiencing treatment resistance or metastatic disease.
✕Less likely to help
Patients with other types of lung cancer or those who are not diagnosed with cancer may not receive any benefit from this research.
What this research studies
This research explores the role of propionate metabolism in the progression and treatment resistance of non-small cell lung cancer (NSCLC). It aims to identify non-genetic mechanisms that contribute to cancer metastasis and resistance to therapies, focusing on a metabolic byproduct called methylmalonic acid (MMA). The study will analyze how MMA influences cancer cell behavior and its potential as a target for new treatments. Patients may be involved in providing serum samples to help understand the relationship between propionate metabolism and lung cancer.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve treatment outcomes for patients with non-small cell lung cancer.
How similar studies have gone: While the specific focus on propionate metabolism in lung cancer is novel, previous research has shown success in targeting metabolic pathways to improve cancer treatment outcomes.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Parang, Bobak — Weill Medical Coll of Cornell Univ
- Study coordinator: Parang, Bobak
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.