Investigating how proline metabolism affects blood vessel function in pulmonary arterial hypertension.
Endothelial Proline Utilization in Pulmonary Arterial Hypertension
This study is looking at how a substance called proline affects blood vessel changes in people with pulmonary arterial hypertension (PAH), and it hopes to find new ways to help treat this condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10864353 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of proline metabolism in pulmonary arterial hypertension (PAH), a condition that leads to severe complications like right ventricular failure. By using advanced imaging techniques and systems biology, the study aims to identify how proline dysregulation contributes to the remodeling of blood vessels in PAH. The research will involve both laboratory studies on endothelial cells and analysis of human samples to uncover metabolic changes associated with early-stage PAH. Patients may benefit from insights that could lead to new therapeutic strategies targeting metabolic pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with early-stage pulmonary arterial hypertension.
Not a fit: Patients with advanced pulmonary arterial hypertension or those not diagnosed with the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with pulmonary arterial hypertension.
How similar studies have performed: Previous research has shown promising results in understanding metabolic pathways in other cardiovascular conditions, suggesting potential for success in this novel approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Wertheim, Bradley — Brigham and Women's Hospital
- Study coordinator: Wertheim, Bradley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.