Investigating how progranulin affects inflammation through its interaction with TNFR2.
The immunological mechanism of PGRNs anti-inflammatory effect
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10912299
This study is looking at how a protein called progranulin helps control inflammation in the body by working with a specific receptor, which could lead to new ways to treat inflammatory diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10912299 on ClinicalTrials.gov |
What this research studies
This research explores the role of progranulin (PGRN) in regulating inflammation by focusing on its interaction with the TNFR2 receptor. By examining how PGRN influences the behavior of immune cells, particularly macrophages, the study aims to uncover the mechanisms behind its anti-inflammatory effects. The researchers will utilize genetic screening and proteomics to identify key signaling molecules involved in this process. This work could lead to new insights into treating inflammatory diseases by harnessing the protective properties of PGRN.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals suffering from chronic inflammatory conditions.
Not a fit: Patients with acute inflammatory responses or those not affected by chronic inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapeutic strategies for managing inflammatory diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of TNFR2 in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, CHUANJU — YALE UNIVERSITY
- Study coordinator: LIU, CHUANJU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.