Investigating how progranulin affects inflammation through its interaction with TNFR2.
Official title: The immunological mechanism of PGRNs anti-inflammatory effect
Funded at Yale University · NIH-10912299 · Data updated 2026-11-12
This study is looking at how a protein called progranulin helps control inflammation in the body by working with a specific receptor, which could lead to new ways to treat inflammatory diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 3, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $530,622 |
| NIH project number | 7R01AR062207-11 |
| Project ID | NIH-10912299 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals suffering from chronic inflammatory conditions.
✕Less likely to help
Patients with acute inflammatory responses or those not affected by chronic inflammation may not benefit from this research.
What this research studies
This research explores the role of progranulin (PGRN) in regulating inflammation by focusing on its interaction with the TNFR2 receptor. By examining how PGRN influences the behavior of immune cells, particularly macrophages, the study aims to uncover the mechanisms behind its anti-inflammatory effects. The researchers will utilize genetic screening and proteomics to identify key signaling molecules involved in this process. This work could lead to new insights into treating inflammatory diseases by harnessing the protective properties of PGRN.
Why it matters
Potential benefit: If successful, this research could lead to novel therapeutic strategies for managing inflammatory diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of TNFR2 in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Liu, Chuanju — Yale University
- Study coordinator: Liu, Chuanju
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.