Investigating how problems with cell recycling affect allergic asthma
Study the link of autophagy dysfunction to allergic and neutrophilic asthma onset
['FUNDING_R01'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-10873295
This study is looking at how a process in our immune cells called autophagy affects asthma and allergies, and it aims to find out if boosting this process can help reduce asthma symptoms caused by allergens.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-10873295 on ClinicalTrials.gov |
What this research studies
This research aims to understand the immune processes that lead to allergic diseases and asthma, focusing on a cellular process called autophagy, which helps maintain healthy immune function. The study will explore how disruptions in autophagy, particularly in immune cells known as dendritic cells, can lead to severe asthma symptoms. By using animal models, researchers will test whether enhancing autophagy can reduce airway hyperreactivity caused by allergens. The findings could provide insights into new treatment strategies for asthma and allergic conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals, particularly children, who suffer from allergic asthma or related allergic conditions.
Not a fit: Patients with non-allergic asthma or those whose asthma is not influenced by immune mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve asthma management and reduce symptoms for patients with allergic asthma.
How similar studies have performed: Previous studies have shown promising results in understanding the role of autophagy in asthma, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AKBARI, OMID — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: AKBARI, OMID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Allergic Disease