Investigating how problems in the hypothalamus may speed up aging in people.
The Role of Hypothalamic Dysfunction in Accelerating Aging in Humans
This study is looking at how problems in a part of the brain called the hypothalamus might speed up aging in older adults, and it hopes to find clues that could help us understand and possibly prevent issues like memory loss and weakness as we get older.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11088929 on NIH RePORTER |
What this research studies
This research explores the role of hypothalamic dysfunction in the aging process of humans. It aims to understand how issues in the hypothalamus, which is crucial for regulating metabolism and hormonal balance, may lead to accelerated aging. The study will assess two key indicators of hypothalamic dysfunction: neuroendocrine dysregulation and structural changes in the hypothalamus, using advanced neuroimaging techniques. By examining these factors in older adults, the research seeks to identify potential predictors of cognitive decline and frailty associated with aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 65 and older who may be experiencing cognitive decline or other signs of accelerated aging.
Not a fit: Patients under the age of 65 or those without signs of cognitive decline or frailty may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and interventions that slow down the aging process and improve the quality of life for older adults.
How similar studies have performed: While there is emerging evidence from animal studies regarding hypothalamic dysfunction and aging, this research represents a novel approach to understanding these mechanisms in humans.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Aleksic, Sandra — Albert Einstein College of Medicine
- Study coordinator: Aleksic, Sandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.