Investigating how pressure-sensitive channels in the eye contribute to glaucoma
Official title: The Role of Mechanosensitive Ion Channels in Glaucoma
Funded at Stanford University · NIH-10896129 · Data updated 2026-11-12
This study is looking at how certain channels in the eye respond to pressure changes and may help us find new ways to treat glaucoma, which can cause vision loss, by exploring the genetics behind it and testing in the lab and with mice.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $241,001 |
| NIH project number | 5K08EY034600-02 |
| Project ID | NIH-10896129 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for glaucoma, particularly those with a family history of the condition or genetic variants linked to increased risk.
✕Less likely to help
Patients who do not have glaucoma or are not at risk for developing the condition may not benefit from this research.
What this research studies
This research focuses on understanding the role of mechanosensitive ion channels in glaucoma, a condition that can lead to vision loss. The study will utilize human genetic analyses, laboratory experiments, and mouse models to explore how these channels respond to changes in eye pressure and contribute to the death of retinal cells. By identifying specific genetic variants associated with glaucoma, the research aims to uncover new therapeutic targets that could improve treatment options for patients. The approach combines both in vitro and in vivo methodologies to provide a comprehensive understanding of the mechanisms involved.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating glaucoma, potentially preserving vision for many patients.
How similar studies have gone: Previous research has shown promise in understanding the role of mechanosensitive channels in other conditions, suggesting that this approach could yield valuable insights for glaucoma as well.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Liu, Wendy W. — Stanford University
- Study coordinator: Liu, Wendy W.
Related research
Other NIH-funded projects on the same topics.
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IOP and CSF Pressure in Glaucoma Risk
This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.
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This trial compares two tube placements for glaucoma drainage implants to see which better protects corneal cells and controls eye pressure in people with uncontrolled glaucoma.
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Using AI on eye scans and genes to predict glaucoma risk
This project uses artificial intelligence on eye scans, vision tests, and genetic information to find people most likely to develop or have worsening glaucoma.
-
AI-based glaucoma screening in community health centers
A new, easy-to-use AI screening approach will be tested in federally funded health centers to help identify people at risk for glaucoma, especially in communities with higher risk.
-
Understanding how glaucoma genes control eye cell function
A long-term research project will study how genetic factors affect eye cells in adults with glaucoma to uncover new ideas for protecting vision.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.