Investigating how pressure-sensitive channels in the eye contribute to glaucoma
The Role of Mechanosensitive Ion Channels in Glaucoma
['FUNDING_CAREER'] · STANFORD UNIVERSITY · NIH-10896129
This study is looking at how certain channels in the eye respond to pressure changes and may help us find new ways to treat glaucoma, which can cause vision loss, by exploring the genetics behind it and testing in the lab and with mice.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10896129 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of mechanosensitive ion channels in glaucoma, a condition that can lead to vision loss. The study will utilize human genetic analyses, laboratory experiments, and mouse models to explore how these channels respond to changes in eye pressure and contribute to the death of retinal cells. By identifying specific genetic variants associated with glaucoma, the research aims to uncover new therapeutic targets that could improve treatment options for patients. The approach combines both in vitro and in vivo methodologies to provide a comprehensive understanding of the mechanisms involved.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for glaucoma, particularly those with a family history of the condition or genetic variants linked to increased risk.
Not a fit: Patients who do not have glaucoma or are not at risk for developing the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating glaucoma, potentially preserving vision for many patients.
How similar studies have performed: Previous research has shown promise in understanding the role of mechanosensitive channels in other conditions, suggesting that this approach could yield valuable insights for glaucoma as well.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, WENDY W. — STANFORD UNIVERSITY
- Study coordinator: LIU, WENDY W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.