Investigating how prenatal stress affects depression and health differences between sexes.
Sex Differences in Major Depression: Impact of Prenatal Stress-Immune and Autonomic Dysregulation
['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10766719
This study is looking at how stress during pregnancy might affect the chances of developing depression and other health issues later on, especially in women, and it aims to find early signs that could help us understand and prevent these problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10766719 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how prenatal stress impacts the development of major depressive disorder (MDD) and related health issues, particularly in women. It examines the differences in brain circuitry and immune responses between sexes, aiming to identify early biomarkers that could indicate a higher risk for MDD and autonomic dysregulation. By studying these factors from fetal development through midlife, the research seeks to uncover critical insights that could lead to early interventions and improved health outcomes for those affected. The approach combines various scientific disciplines to translate findings into practical applications for patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research include women who are pregnant or have experienced prenatal stress and may be at risk for major depressive disorder.
Not a fit: Patients who do not have a history of prenatal stress or major depressive disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier identification and intervention strategies for women at risk of major depression and related health complications.
How similar studies have performed: Previous research has shown promising results in understanding sex differences in stress responses and their implications for mental health, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOLDSTEIN, JILL M — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: GOLDSTEIN, JILL M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.