Investigating how prenatal factors affect brain development and neurodevelopmental disorders.
Prenatal Origins of Neurometabolic Consequences
This study is looking at how certain health problems during pregnancy, like issues with the placenta and low blood sugar, might be connected to neurodevelopmental disorders in kids, such as autism, and aims to create helpful tools and diets to support better outcomes for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10908423 on NIH RePORTER |
What this research studies
This research explores the links between prenatal health issues, such as placental disorders and low glucose levels, and the development of neurodevelopmental disorders (NDDs) in children. By studying genetic mutations and their interaction with the intra-uterine environment, the research aims to understand how these factors contribute to conditions like autism and cognitive disabilities. The team is developing diagnostic tools and dietary interventions, such as ketogenic diets, to improve outcomes for affected individuals. The use of human brain organoids and animal models will help in assessing the impact of these interventions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include pregnant individuals at risk of placental disorders and children diagnosed with neurodevelopmental disorders.
Not a fit: Patients with neurodevelopmental disorders not linked to prenatal factors or genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostics and dietary strategies that enhance brain development and reduce the incidence of neurodevelopmental disorders.
How similar studies have performed: Previous research has shown promising results in understanding the prenatal origins of neurodevelopmental disorders, indicating that this approach has potential for success.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Devaskar, Sherin U — University of California Los Angeles
- Study coordinator: Devaskar, Sherin U
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.