Investigating how prenatal exposure to PFAS chemicals affects adolescent heart and metabolic health
Gestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic Health
['FUNDING_R01'] · BROWN UNIVERSITY · NIH-10893411
This study is looking at how being exposed to certain chemicals during pregnancy might affect kids' health as they grow up, especially regarding weight and how their bodies handle sugar, by checking blood samples from moms and their children.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROWN UNIVERSITY (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-10893411 on ClinicalTrials.gov |
What this research studies
This research examines the impact of prenatal exposure to perfluoroalkyl substances (PFAS) on the long-term health of adolescents, particularly focusing on cardiometabolic conditions such as obesity and insulin resistance. By analyzing blood samples from pregnant women and their children, the study aims to identify how these chemical exposures influence metabolic profiles over time. The research utilizes advanced metabolomics techniques to uncover biological pathways that may be affected by PFAS exposure, providing insights into potential health risks for children as they grow into adulthood.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women and their children, particularly those exposed to PFAS through contaminated water or food.
Not a fit: Patients who are not pregnant or do not have children may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for cardiometabolic diseases in adolescents linked to environmental exposures.
How similar studies have performed: While there is existing research on PFAS exposure, this study's focus on PFAS mixtures and their long-term effects on adolescent health is relatively novel and underexplored.
Where this research is happening
PROVIDENCE, UNITED STATES
- BROWN UNIVERSITY — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRAUN, JOSEPH M — BROWN UNIVERSITY
- Study coordinator: BRAUN, JOSEPH M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.