Investigating how prenatal exposure to certain chemicals affects breast cancer risk
Defining the role of in utero estrogenic endocrine disruption on mammary gland stiffness and breast cancer risk
This study is looking at how being exposed to certain chemicals during pregnancy might affect the risk of breast cancer in daughters later in life, and it aims to find out how these chemicals change breast tissue in ways that could make cancer more likely.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11093459 on NIH RePORTER |
What this research studies
This research focuses on understanding how exposure to estrogenic endocrine disrupting compounds (EDCs) during pregnancy can influence breast cancer risk in daughters. The study aims to identify the biological mechanisms that link EDC exposure to changes in the mammary gland, particularly looking at how these chemicals can alter the structure and stiffness of breast tissue. By using a mouse model, researchers will explore how these changes may increase susceptibility to cancer and seek to develop biological markers that can help assess risk from EDC exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who were exposed to estrogenic EDCs during pregnancy or have a family history of breast cancer.
Not a fit: Patients who have not been exposed to estrogenic EDCs or do not have a family history of breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for breast cancer linked to environmental exposures.
How similar studies have performed: Previous research has shown a connection between EDC exposure and increased cancer risk, but this specific approach to understanding the mechanisms is relatively novel.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Burd, Craig J — Ohio State University
- Study coordinator: Burd, Craig J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.