Investigating how prenatal exposure to androgens affects fertility-related brain cells
Development of the GnRH neuronal network and effects of prenatal androgen exposure
This study is looking at how being exposed to certain hormones before birth affects the brain cells that help control fertility, especially in women with polycystic ovary syndrome (PCOS), to better understand fertility issues and find new ways to help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11004645 on NIH RePORTER |
What this research studies
This research focuses on understanding how exposure to androgens before birth influences the development of gonadotropin-releasing hormone (GnRH) neurons, which are crucial for regulating fertility. By studying prenatally androgenized mice, the research aims to uncover the neurobiological mechanisms that lead to fertility issues, particularly in women with polycystic ovary syndrome (PCOS). The study will explore changes in neuron activity and synaptic connections, providing insights into how these alterations may contribute to reproductive health problems. The findings could help identify early indicators of fertility disorders and inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include women with polycystic ovary syndrome or those experiencing fertility issues related to hormonal imbalances.
Not a fit: Patients who do not have hormonal imbalances or fertility issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of fertility issues in women, particularly those affected by PCOS.
How similar studies have performed: Previous research has shown promising results in understanding the neuroendocrine mechanisms related to fertility, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Moenter, Suzanne M — University of Michigan at Ann Arbor
- Study coordinator: Moenter, Suzanne M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.