Investigating how pregnancy affects the use and safety of new HIV medications in women.
Understanding Medication Adherence Benchmarks, Safety and Pharmacometrics of Novel Antiretrovirals in Pregnant Women Living with HIV.
This study is looking at how pregnancy affects the way a new HIV medication works in women who are pregnant, to ensure the medicine is safe and that moms can stick to their treatment, which is important for their health and for keeping their babies healthy too.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10907720 on NIH RePORTER |
What this research studies
This research focuses on understanding how pregnancy influences the pharmacology of novel antiretroviral medications in women living with HIV. It aims to assess medication adherence and safety of these drugs during pregnancy, which is crucial for both maternal health and preventing HIV transmission to infants. The study will involve characterizing the pharmacokinetics of a specific drug, tenofovir alafenamide, and establishing benchmarks for adherence in pregnant women. By collaborating with experts in pharmacometrics, the research seeks to fill existing knowledge gaps in treating this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women living with HIV, particularly those in their second or third trimester.
Not a fit: Patients who are not pregnant or those who do not have HIV may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for pregnant women living with HIV, enhancing their health and reducing the risk of HIV transmission to their babies.
How similar studies have performed: Previous research has shown success in similar pharmacological studies involving pregnant populations, indicating a promising avenue for this investigation.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Eke, Ahizechukwu C. — Johns Hopkins University
- Study coordinator: Eke, Ahizechukwu C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.