Investigating how pregnancy affects immunity from RSV vaccines
Evaluation of pregnancy on vaccine-induced immunity and protection in a pre-clinical model of RSV infection
['FUNDING_R01'] · UNIVERSITY OF GEORGIA · NIH-10685614
This study is looking at how giving vaccines to pregnant moms can help protect their babies from respiratory syncytial virus (RSV) by boosting the mom's immune system and passing on helpful antibodies to the baby.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF GEORGIA (nih funded) |
| Locations | 1 site (ATHENS, UNITED STATES) |
| Trial ID | NIH-10685614 on ClinicalTrials.gov |
What this research studies
This research explores the impact of maternal immunization on the immune response to respiratory syncytial virus (RSV) in a pre-clinical model. It aims to develop a novel vaccination strategy that could enhance maternal immunity and provide protective antibodies to infants during their most vulnerable period. By testing these strategies, the research seeks to address previous challenges in RSV vaccine development, particularly the risk of enhanced respiratory disease in infants. The approach involves evaluating the effectiveness of passive transfer of neutralizing antibodies from mothers to infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who may passively transfer immunity to their infants.
Not a fit: Patients who are not pregnant or who do not have infants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of an effective RSV vaccine that protects infants from severe respiratory infections.
How similar studies have performed: Previous research has shown promise in maternal immunization strategies for other infections, suggesting potential success for this novel approach in RSV.
Where this research is happening
ATHENS, UNITED STATES
- UNIVERSITY OF GEORGIA — ATHENS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NORRIS, KAREN A — UNIVERSITY OF GEORGIA
- Study coordinator: NORRIS, KAREN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.