Investigating how PPARD affects the progression of pancreatic cancer
Official title: PPARD hyperactivation promotes pancreatic intraepithelial neoplasia progression into pancreatic ductal adenocarcinoma
Funded at University of Michigan at Ann Arbor · NIH-11036308 · Data updated 2026-11-12
This study is looking at how certain diets and genetic changes might help us understand how early signs of pancreatic cancer develop into the disease, using mice to find new ways to prevent or treat pancreatic cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | February 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $642,368 |
| NIH project number | 5R01CA273732-02 |
| Project ID | NIH-11036308 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with precursors to pancreatic cancer, particularly those with pancreatic intraepithelial neoplasms.
✕Less likely to help
Patients who have already been diagnosed with advanced pancreatic ductal adenocarcinoma may not benefit from this research.
What this research studies
This research focuses on understanding the role of PPARD in the progression of pancreatic intraepithelial neoplasms (PanINs) to pancreatic ductal adenocarcinoma (PDA). It utilizes mouse models to study how dietary factors and genetic mutations influence this progression. By examining the effects of high-fat diets and specific genetic alterations, the research aims to uncover the mechanisms that drive the transition from precancerous lesions to invasive cancer. This could lead to new insights into potential therapeutic targets for preventing or treating pancreatic cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing the progression of pancreatic cancer in at-risk individuals.
How similar studies have gone: Previous research has shown that targeting specific pathways in cancer progression can lead to significant advancements in treatment, suggesting that this approach may also yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Shureiqi, Imad — University of Michigan at Ann Arbor
- Study coordinator: Shureiqi, Imad
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.