Investigating how PPARD affects the progression of pancreatic cancer
PPARD hyperactivation promotes pancreatic intraepithelial neoplasia progression into pancreatic ductal adenocarcinoma
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11036308
This study is looking at how certain diets and genetic changes might help us understand how early signs of pancreatic cancer develop into the disease, using mice to find new ways to prevent or treat pancreatic cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11036308 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of PPARD in the progression of pancreatic intraepithelial neoplasms (PanINs) to pancreatic ductal adenocarcinoma (PDA). It utilizes mouse models to study how dietary factors and genetic mutations influence this progression. By examining the effects of high-fat diets and specific genetic alterations, the research aims to uncover the mechanisms that drive the transition from precancerous lesions to invasive cancer. This could lead to new insights into potential therapeutic targets for preventing or treating pancreatic cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with precursors to pancreatic cancer, particularly those with pancreatic intraepithelial neoplasms.
Not a fit: Patients who have already been diagnosed with advanced pancreatic ductal adenocarcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing the progression of pancreatic cancer in at-risk individuals.
How similar studies have performed: Previous research has shown that targeting specific pathways in cancer progression can lead to significant advancements in treatment, suggesting that this approach may also yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHUREIQI, IMAD — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: SHUREIQI, IMAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.