Investigating how polyphosphate affects heart fibrosis caused by a parasite.
Polyphosphate and cardiac fibrosis by Trypanosoma cruzi
This study is looking at how a substance called polyphosphate affects heart problems in people with Chagas disease, aiming to find new ways to treat heart issues caused by this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-10850804 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of polyphosphate in the development of cardiac fibrosis associated with Chagas disease, which is caused by the parasite Trypanosoma cruzi. The study examines how polyphosphate influences fibroblast behavior, leading to excessive extracellular matrix accumulation and heart dysfunction. By exploring the mechanisms of fibrosis and the potential reversibility of these processes with specific treatments, the research aims to uncover new therapeutic targets for patients suffering from Chagas disease-related heart issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Chagas disease who are experiencing cardiac symptoms.
Not a fit: Patients without Chagas disease or those whose heart issues are unrelated to this condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse heart damage in patients with Chagas disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of polyphosphate in fibrosis, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Docampo, Roberto — University of Georgia
- Study coordinator: Docampo, Roberto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.