Investigating how polyamine metabolism affects stomach inflammation and disease from H. pylori infection
Official title: "Dysregulated Polyamine Metabolism in H. pylori-associated Gastric Inflammation and Disease Progression"
Funded at Veterans Health Administration · NIH-11045486 · Data updated 2026-11-12
This study is looking at how certain natural compounds in the body, called polyamines, might affect stomach problems caused by a common bacteria, Helicobacter pylori, especially in veterans, to help understand how these issues can lead to conditions like chronic gastritis and ulcers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| NIH project number | 2I01CX002171-06 |
| Project ID | NIH-11045486 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans who have been diagnosed with H. pylori infection and are experiencing gastric inflammation or related symptoms.
✕Less likely to help
Patients who do not have H. pylori infection or those with unrelated gastric conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of polyamines in gastric diseases caused by Helicobacter pylori, a common bacterial infection among veterans. The study examines how changes in polyamine metabolism can lead to chronic gastritis, peptic ulcers, and potentially gastric cancer. By analyzing gastric epithelial cells and their response to H. pylori, researchers aim to identify mechanisms that contribute to inflammation and disease progression. The approach includes studying the effects of specific enzymes involved in polyamine synthesis and their impact on gastric health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or mitigate gastric inflammation and reduce the risk of gastric cancer in patients infected with H. pylori.
How similar studies have gone: Previous research has shown promising results in understanding the role of polyamines in gastric diseases, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Veterans Health Administration
Nashville, United States Active
Researchers
- Principal investigator: Wilson, Keith T. — Veterans Health Administration
- Study coordinator: Wilson, Keith T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.