Investigating how polyamine metabolism affects heart disease
Official title: Dysregulations in Polyamine Metabolism During Atherosclerosis
Funded at Louisiana State Univ Hsc Shreveport · NIH-11046599 · Data updated 2026-11-12
This study is looking at how certain substances in our bodies, called polyamines, might affect heart health and lead to problems like heart attacks and strokes, with the hope of finding new ways to help people with heart disease feel better and stay healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $509,960 |
| NIH project number | 5R01HL167758-03 |
| Project ID | NIH-11046599 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with atherosclerotic cardiovascular disease or those at high risk for developing heart disease.
✕Less likely to help
Patients without cardiovascular disease or those who do not have risk factors for atherosclerosis may not benefit from this research.
What this research studies
This research focuses on understanding the role of polyamine metabolism in atherosclerotic cardiovascular disease (CVD), which is a leading cause of death worldwide. It aims to uncover how dysregulation of polyamines contributes to inflammation and structural changes in blood vessels, which can lead to heart attacks and strokes. By studying the cellular mechanisms involved, the research seeks to identify new therapeutic strategies that could prevent the progression of CVD. Patients may benefit from insights that could lead to innovative treatments targeting the underlying causes of their cardiovascular issues.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of heart attacks and strokes by targeting the mechanisms of vascular inflammation and remodeling.
How similar studies have gone: Previous research has shown that targeting inflammation and vascular remodeling can be beneficial, but this specific approach focusing on polyamine metabolism is relatively novel.
Where this research is happening
-
Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Yurdagul, Arif — Louisiana State Univ Hsc Shreveport
- Study coordinator: Yurdagul, Arif
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.