Investigating how pollutants cause nerve cell damage in Parkinson's disease
Which mechanisms of pollutant-induced mitochondrial dysfunction cause dopaminergic neurodegeneration?
This study is looking at how certain environmental pollutants might harm the tiny powerhouses in our cells, which could lead to problems with movement and contribute to Parkinson's disease, helping us find ways to prevent or treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10954711 on NIH RePORTER |
What this research studies
This research explores the mechanisms by which environmental pollutants lead to mitochondrial dysfunction and contribute to the degeneration of dopaminergic neurons, which are crucial for movement control. By examining various chemicals that may affect mitochondrial function, the study aims to identify specific pathways that lead to Parkinson's disease. The approach includes laboratory experiments and toxicological screenings to prioritize which chemicals should be tested further for their impact on nerve cells. This research could provide insights into both prevention and treatment strategies for Parkinson's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over the age of 60 who are at risk for or have been diagnosed with Parkinson's disease.
Not a fit: Patients with Parkinson's disease who are not exposed to environmental pollutants or who have other unrelated causes of neurodegeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventive measures and therapies for Parkinson's disease, potentially slowing its progression.
How similar studies have performed: Previous research has shown success in identifying environmental factors contributing to Parkinson's disease, but this specific approach to prioritizing chemical testing is relatively novel.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Meyer, Joel Newman — Duke University
- Study coordinator: Meyer, Joel Newman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.