Investigating how Poldip2 affects the blood-brain barrier's integrity
Official title: Poldip2 and the Brain Endothelial Barrier Function: Understanding Mechanisms that Regulate the Blood Brain Barrier Integrity
Funded at Emory University · NIH-11111432 · Data updated 2026-11-12
This study is looking at a protein called Poldip2 to see how it helps keep the blood-brain barrier safe, especially during events like strokes or brain injuries, and it aims to find ways to protect the brain better in these situations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 21, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $433,636 |
| NIH project number | 5R01NS127964-03 |
| Project ID | NIH-11111432 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or experiencing conditions that compromise the blood-brain barrier, such as stroke or brain trauma.
✕Less likely to help
Patients with conditions unrelated to blood-brain barrier integrity or those not experiencing neurological issues may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called Poldip2 in maintaining the integrity of the blood-brain barrier (BBB), which is crucial for protecting the brain from harmful substances. The study will explore how the deletion of Poldip2 in specific brain cells can prevent damage to the BBB during conditions like stroke and brain trauma. By using both animal models and in vitro experiments, researchers aim to uncover the mechanisms that regulate the BBB and how they can be targeted for therapeutic purposes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect the brain from damage during neurological events such as strokes.
How similar studies have gone: Previous studies have shown promising results in understanding blood-brain barrier mechanisms, suggesting that this approach could yield significant insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Hernandes, Marina Sorrentino — Emory University
- Study coordinator: Hernandes, Marina Sorrentino
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.