Investigating how polarity proteins affect gut barrier function and healing
Polarity proteins and intestinal mucosal responses to inflammation and injury
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11042816
This study is looking at how a special protein called Crumbs 3 helps keep the gut healthy and heal after injury, which could lead to new treatments for people with gut problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11042816 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of polarity proteins, specifically Crumbs 3, in maintaining the integrity of the intestinal barrier and facilitating wound repair. By using transgenic mice and human intestinal samples, the study aims to uncover the mechanisms by which these proteins regulate cell junctions and epithelial homeostasis. Patients may benefit from insights gained about how inflammation and injury impact gut health, potentially leading to new therapeutic strategies for gastrointestinal disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from gastrointestinal disorders that involve inflammation or injury to the intestinal epithelium.
Not a fit: Patients with stable gastrointestinal conditions that do not involve inflammation or epithelial injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions that compromise gut barrier function, such as inflammatory bowel disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of cell junctions in gut health, suggesting that this approach could yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NUSRAT, ASMA — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: NUSRAT, ASMA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.