Investigating how platelets contribute to the growth of abdominal aortic aneurysms
Platelets as Biosensors and Mediators of Aortic Aneurysm Growth
This study is looking at how platelets in your blood might affect the growth of abdominal aortic aneurysms and whether taking medications like aspirin could help slow that growth, with the goal of finding better ways to manage your condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10874516 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of platelets in the progression of abdominal aortic aneurysms (AAA), which can lead to life-threatening ruptures. It examines how activated platelets and their aggregates may influence the growth of these aneurysms and explores the potential of antiplatelet medications, like aspirin, to mitigate this risk. By using a specialized system that mimics the turbulent blood flow in aneurysms, the study aims to identify new biological markers and therapeutic targets that could help manage AAA growth more effectively. Patients with AAA may benefit from insights gained about their condition and potential new treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who have been diagnosed with asymptomatic abdominal aortic aneurysms.
Not a fit: Patients without abdominal aortic aneurysms or those under 65 years of age may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of abdominal aortic aneurysm growth and rupture.
How similar studies have performed: Previous research has shown promising results in understanding the role of platelets in vascular conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Cameron, Scott James — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Cameron, Scott James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.