Investigating how platelets and fibroblasts interact in pulmonary arterial hypertension related to systemic sclerosis.
A platelet-fibroblast axis connecting bioenergetics and metabolism in SSc-pulmonary arterial hypertension
This study is looking at how platelets and fibroblasts work together in people with pulmonary arterial hypertension related to systemic sclerosis, to find new ways to diagnose the condition and create better treatments that could help improve your health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10929347 on NIH RePORTER |
What this research studies
This research focuses on understanding the complex interactions between platelets and fibroblasts in patients with pulmonary arterial hypertension (PAH) associated with systemic sclerosis (SSc-PAH). The team aims to explore how changes in platelet energy metabolism can influence fibroblast behavior, particularly in relation to glutamine metabolism and collagen deposition, which are critical in the development of vascular stiffness. By examining these cellular interactions, the research seeks to identify potential biomarkers for diagnosing SSc-PAH and to develop targeted therapies that could improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic sclerosis who are also experiencing pulmonary arterial hypertension.
Not a fit: Patients without systemic sclerosis or those not affected by pulmonary arterial hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and treatment strategies for patients suffering from SSc-PAH.
How similar studies have performed: Previous research has shown promising results in understanding the role of cellular metabolism in vascular diseases, indicating that this approach may yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Chan, Stephen Y — University of Pittsburgh at Pittsburgh
- Study coordinator: Chan, Stephen Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.