Investigating how platelets and eosinophils interact in COPD
Role of platelet-eosinophil interactions in COPD morbidity
['FUNDING_R03'] · JOHNS HOPKINS UNIVERSITY · NIH-11056015
This study is looking at how certain blood cells called platelets and eosinophils work together in people with chronic obstructive pulmonary disease (COPD) to better understand the inflammation that makes the condition worse, with hopes of finding new treatments to help manage COPD symptoms.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11056015 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the interactions between platelets and eosinophils in patients with chronic obstructive pulmonary disease (COPD). By measuring platelet-eosinophil conjugates and eosinophil activation through flow cytometry, the study aims to uncover the mechanisms behind type-2 inflammation in COPD. The goal is to identify how these interactions contribute to the morbidity associated with COPD, which could lead to new targeted therapies. Patients with COPD will be the primary subjects of this investigation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic obstructive pulmonary disease (COPD).
Not a fit: Patients with other respiratory conditions that do not involve eosinophilic inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that specifically target the inflammatory processes in COPD, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of eosinophils in asthma, but this specific approach in COPD is relatively novel.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FAWZY, ASHRAF — JOHNS HOPKINS UNIVERSITY
- Study coordinator: FAWZY, ASHRAF
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.