Investigating how platelets and eosinophils interact in COPD
Official title: Role of platelet-eosinophil interactions in COPD morbidity
Funded at Johns Hopkins University · NIH-11056015 · Data updated 2026-11-12
This study is looking at how certain blood cells called platelets and eosinophils work together in people with chronic obstructive pulmonary disease (COPD) to better understand the inflammation that makes the condition worse, with hopes of finding new treatments to help manage COPD symptoms.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $122,813 |
| NIH project number | 5R03HL173072-02 |
| Project ID | NIH-11056015 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic obstructive pulmonary disease (COPD).
✕Less likely to help
Patients with other respiratory conditions that do not involve eosinophilic inflammation may not benefit from this research.
What this research studies
This research focuses on understanding the interactions between platelets and eosinophils in patients with chronic obstructive pulmonary disease (COPD). By measuring platelet-eosinophil conjugates and eosinophil activation through flow cytometry, the study aims to uncover the mechanisms behind type-2 inflammation in COPD. The goal is to identify how these interactions contribute to the morbidity associated with COPD, which could lead to new targeted therapies. Patients with COPD will be the primary subjects of this investigation.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that specifically target the inflammatory processes in COPD, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the role of eosinophils in asthma, but this specific approach in COPD is relatively novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Fawzy, Ashraf — Johns Hopkins University
- Study coordinator: Fawzy, Ashraf
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.