Investigating how platelets affect inflammation in aortic aneurysms
Origin and Immune Functions of Platelets in Aortic Aneurysms
This study is looking at how platelets, especially those from the lungs, might play a role in the growth and worsening of abdominal aortic aneurysms (AAA), with the hope of finding new ways to treat this serious condition and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10661563 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of platelets in the development and progression of abdominal aortic aneurysms (AAA), a serious vascular condition. It aims to explore how platelets, particularly those derived from the lungs, contribute to inflammation and the degradation of the extracellular matrix, which can lead to life-threatening ruptures. By examining the interactions between platelets and immune cells, specifically macrophages, the study seeks to uncover new mechanisms that could inform future therapies. Patients may benefit from insights that could lead to improved treatment options for AAA.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with abdominal aortic aneurysms or those at high risk for developing this condition.
Not a fit: Patients without aortic aneurysms or those with other unrelated vascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that prevent the progression of aortic aneurysms and reduce the risk of rupture.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in vascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Ramkhelawon, Bhama — New York University School of Medicine
- Study coordinator: Ramkhelawon, Bhama
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.