Investigating how platelet changes after injury can predict organ failure.
Official title: The Platelet Transcriptome and Organ Failure After Injury: Discovering Molecular Biomarkers and Preventative Targets through Interrogating Novel RNA Modifications
Funded at University of California, San Francisco · NIH-10890084 · Data updated 2026-11-12
This study is looking at how platelets, which help your blood clot, change after an injury and how those changes might lead to problems with your organs, so we can find ways to predict and prevent complications for patients who have been hurt.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $403,750 |
| NIH project number | 5R35GM150656-02 |
| Project ID | NIH-10890084 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced significant trauma or injury.
✕Less likely to help
Patients who have not experienced any recent injuries or trauma may not benefit from this research.
What this research studies
This research focuses on understanding how platelets, which are crucial for blood clotting, change after an injury and how these changes can lead to organ failure. By analyzing the RNA modifications in platelets, the study aims to identify biomarkers that can help predict which patients are at risk for complications after trauma. The approach involves advanced techniques to examine the molecular changes in platelets, providing insights into their role in post-injury recovery. This could lead to new therapies aimed at preventing organ failure in injured patients.
Why it matters
Potential benefit: If successful, this research could lead to early identification of patients at risk for organ failure after injury, allowing for timely interventions.
How similar studies have gone: Previous research has shown promise in using platelet transcriptomics to understand disease mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Kornblith, Lucy Zumwinkle — University of California, San Francisco
- Study coordinator: Kornblith, Lucy Zumwinkle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.