Investigating how platelet changes after injury can predict organ failure.
The Platelet Transcriptome and Organ Failure After Injury: Discovering Molecular Biomarkers and Preventative Targets through Interrogating Novel RNA Modifications
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10890084
This study is looking at how platelets, which help your blood clot, change after an injury and how those changes might lead to problems with your organs, so we can find ways to predict and prevent complications for patients who have been hurt.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10890084 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how platelets, which are crucial for blood clotting, change after an injury and how these changes can lead to organ failure. By analyzing the RNA modifications in platelets, the study aims to identify biomarkers that can help predict which patients are at risk for complications after trauma. The approach involves advanced techniques to examine the molecular changes in platelets, providing insights into their role in post-injury recovery. This could lead to new therapies aimed at preventing organ failure in injured patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced significant trauma or injury.
Not a fit: Patients who have not experienced any recent injuries or trauma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early identification of patients at risk for organ failure after injury, allowing for timely interventions.
How similar studies have performed: Previous research has shown promise in using platelet transcriptomics to understand disease mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KORNBLITH, LUCY ZUMWINKLE — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: KORNBLITH, LUCY ZUMWINKLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.