Investigating how placental hormones affect diabetes during pregnancy
Placental Hormones and O-GlcNAcylation in Gestational Diabetes
This study is looking at how certain nutrients affect the placenta during pregnancy to better understand gestational diabetes, with the goal of finding new and safer treatments for moms and their babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10896316 on NIH RePORTER |
What this research studies
This research focuses on understanding gestational diabetes mellitus (GDM) by examining the role of nutrient-dependent O-GlcNAcylation in placental function. It aims to uncover how changes in placental hormones and glucose levels contribute to the development of GDM, which can lead to complications for both mothers and their children. By studying these mechanisms, the research seeks to identify new, safe, and effective treatments for GDM, which currently have limited options. The approach involves analyzing how O-GlcNAcylation influences hormonal secretion and placental health during pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women diagnosed with gestational diabetes or those at risk of developing it.
Not a fit: Patients who are not pregnant or those with pre-existing type 2 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that prevent or effectively manage gestational diabetes, improving health outcomes for mothers and their babies.
How similar studies have performed: While the specific focus on O-GlcNAcylation in placental function is novel, similar research has shown promise in understanding hormonal regulation in diabetes.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Olivier-Van Stichelen, Stephanie — Medical College of Wisconsin
- Study coordinator: Olivier-Van Stichelen, Stephanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.