Investigating how PKD proteins in blood vessel cells affect blood pressure regulation
PKD proteins in endothelial cells
This study is looking at how two proteins in the cells that line our blood vessels work together to help lower blood pressure, which could help us understand heart and blood vessel problems better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10810639 on NIH RePORTER |
What this research studies
This research focuses on endothelial cells, which line blood vessels and play a crucial role in regulating blood pressure. The study aims to understand how two proteins, PKD1 and PKD2, interact in these cells to promote vasodilation, a process that helps lower blood pressure. By using specialized mouse models, the researchers will explore how these proteins function under normal and hypertensive conditions. The findings could shed light on the mechanisms behind cardiovascular diseases linked to endothelial dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with hypertension or other cardiovascular disorders.
Not a fit: Patients without cardiovascular issues or those not experiencing hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for hypertension and other cardiovascular diseases by targeting the PKD1/PKD2 signaling pathway.
How similar studies have performed: Previous research has shown promising results in understanding endothelial cell function and its implications for cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Jaggar, Jonathan H — University of Tennessee Health Sci Ctr
- Study coordinator: Jaggar, Jonathan H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.