Investigating how PIKfyve affects tumor growth and pH balance in pancreatic cancer
Official title: PIKfyve regulates pH homeostasis and tumor growth in pancreatic cancer
Funded at Sanford Burnham Prebys Medical Discovery Institute · NIH-11067511 · Data updated 2026-11-12
This study is looking at a protein called PIKfyve to see how it affects the growth of pancreatic cancer cells, and it hopes to find new ways to help improve treatment for people battling this tough disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | May 16, 2025 |
| Project end | May 15, 2028 |
| Funding year | 2025 |
| Award (this year) | $40,810 |
| NIH project number | 1F31CA298202-01 |
| Project ID | NIH-11067511 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma who are seeking innovative treatment options.
✕Less likely to help
Patients with other types of cancer or those who do not have pancreatic cancer may not benefit from this research.
What this research studies
This research focuses on pancreatic ductal adenocarcinoma (PDAC), a highly aggressive cancer with a low survival rate. It aims to explore the role of PIKfyve, a protein involved in cellular processes, in regulating the tumor environment and cancer cell growth. By inhibiting PIKfyve using a specific drug, the study will assess its effects on cancer cell survival and proliferation in laboratory settings. The goal is to identify new therapeutic strategies that could improve treatment outcomes for patients with this challenging disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that significantly improve survival rates for patients with pancreatic cancer.
How similar studies have gone: Previous research has shown promising results in targeting PIKfyve in other cancers, suggesting potential for success in pancreatic cancer as well.
Where this research is happening
-
Sanford Burnham Prebys Medical Discovery Institute
La Jolla, United States Active
Researchers
- Principal investigator: Grenier Davis, Shea — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Grenier Davis, Shea
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.