Investigating how Piezo proteins affect gut muscle cells
Piezo-1 & 2’s role in murine intestinal muscularis cells of the SIP syncytium
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11020981
This study is looking at how certain proteins in the muscle cells of your intestines help them respond to stretching, which could lead to better treatments for bowel motility disorders that affect how your intestines work.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11020981 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of Piezo proteins in the muscle cells of the intestines, particularly how they respond to stretching. Bowel motility disorders, which can lead to severe complications like bowel obstruction, are common but not well understood. The study will explore how these proteins help intestinal cells sense stretch and regulate contractions, using advanced techniques to maintain and analyze murine intestinal cells in a controlled environment. By examining these mechanisms, the research aims to uncover new insights that could lead to better treatments for bowel motility issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing bowel motility disorders or bowel obstruction.
Not a fit: Patients with stable bowel function and no history of motility disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from bowel motility disorders and related complications.
How similar studies have performed: While the role of mechanosensors in gut function is an emerging field, similar studies have shown promise in understanding cellular responses to mechanical stimuli.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARTIN, MARTIN G — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: MARTIN, MARTIN G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.