Investigating how piezo channels affect kidney cell function
Role of piezo channels in intercalated cells
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11101293
This study is looking at special kidney cells that help keep your body's acid and salt levels balanced, and it wants to find out how certain channels that respond to pressure affect these cells when fluid flows through the kidneys, which could lead to better treatments for kidney-related issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11101293 on ClinicalTrials.gov |
What this research studies
This research focuses on intercalated cells in the kidney, which play a crucial role in regulating acid-base balance and electrolyte absorption. The study aims to understand how piezo channels, which are sensitive to mechanical changes, influence the function of these cells, particularly in response to fluid flow. By examining the mechanisms behind calcium entry and its effects on cell activity, the research seeks to uncover new insights into kidney physiology and potential therapeutic targets. Patients may benefit from improved understanding of kidney function and related disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are adults over 21 years old with conditions affecting kidney function.
Not a fit: Patients with acute kidney injury or those who are not adults may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for kidney-related conditions by enhancing our understanding of kidney cell function.
How similar studies have performed: Other research has shown promising results in understanding mechanosensitive channels in kidney cells, suggesting that this approach could yield valuable insights.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KLEYMAN, THOMAS R — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: KLEYMAN, THOMAS R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.